Dr. Daniel Kuebler | Franciscan University of Steubenville
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    Dr. Dan Kuebler

    Dean of the School of Natural & Applied Sciences, Professor of Biology

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    Regenerative Medicine Research

    Knee osteoarthritis a common, debilitating condition that is estimated to affect nearly 27 million adults in the United States. Given the nature of this condition, regenerative medicine options hold much promise for treatment. Two common treatment options are fat tissue injections, which represent an abundant source of adult stem cells, and platelet-rich plasma injections. To further the development of such treatments, undergraduate students have been pursing a number of projects. The first involves analyzing and developing new methods to isolate high yields of healthy stem cells from adipose tissue. The second involves determining the effects that activated platelets and other biologics have on gene expression, protein secretion and cell division/growth of adipose-derived stem cells. Finally, we are pursuing animal models of osteoarthritis to test the efficacy of different combinations of these biologics to treat the disorder.

    Read more about this research.

    Research with Seizure Disorders

    Millions of people in the US suffer from epilepsy, a heterogeneous collection of disorders that all involve spontaneous recurrent seizures that have no known trigger. Unfortunately, the etiology of epilepsy is poorly understood particularly given the diverse categories of genes that have been implicated in this disease. In order to understand the underlying cause of seizure disorders such as epilepsy, we study a family of seizure susceptible Drosophila mutants that are known as the Bang-sensitive (BS) paralytic mutants. Uncovering the underlying causative defect in these mutants represents the major line of investigation in our lab. Recently, we have demonstrated that metabolic alterations can have profound effects on seizure susceptibility in the BS mutants. Specifically, we have found that mutations and drugs that increase metabolism can reduce seizure intensity and duration. Undergraduate students, many of whom have presented at national meetings or have been authors on scientific publications, have performed all of this work. Currently we are examining the effect dietary changes have on seizure susceptibility as well as how the expression of metabolic genes is altered by various diets and pharmacological treatments. We hope that a better understanding of the link between metabolism and seizure susceptibility will shed light on the physiological defect(s) underlying seizure disorders in general.

    Selected papers and meeting abstracts with undergraduate student co-authors:

    Stone B, Burke B, Pathakamuri J, Coleman J, Kuebler D. (2014) A low cost method for analyzing seizure-like activity and movement in Drosophila. J Vis Exp. 84: e51460.

    Burner K and Kuebler D. (2014) “Sucrose-only diets suppress seizure-like activity (SLA) in the Bang-sensitive (BS) paralytic mutants easily shocked and technical knockout." (Annual Drosophila Research Conference, Abstr 537C, Mar 26-30).

    Stone B, Kaercher L, ColemanJ, and Kuebler D. (2013) Alterations in metabolism suppress seizures inthe Bang-sensitive paralytic mutants. BrainResearch 1496:94-103.

    Kuebler D, Coleman J., and Stone B.(2013) “Metformin reduces seizure-like activity in the bang-sensitive paralyticmutants easily shocked and technical knockout. (Annual Drosophila ResearchConference, Abstr 470B, Mar 28-Apr 1).

    Kuebler D, Kaercher L, and Stone B. (2011) “Mutationsand drugs that increase metabolism can suppress seizures in the Bang-sensitiveparalytic mutants.” (Annual Drosophila Research Conference, Abstr 417C,Mar 30-Apr 3).

    Whelan J, Burke B, Rice A,Tong M, and Kuebler D. (2010) Sensitivity to seizure-like activity in Drosophila following acute hypoxia and hypercapnia.Brain Research 1326: 120-128.

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